SAINT LAURENT, Quebec, May 09, 2019 (GLOBE NEWSWIRE) -- IntelGenx Technologies Corp. (TSX-V:IGX)(OTCQX:IGXT) (the "Company" or "IntelGenx") today reported financial results for the first quarter ended March 31, 2019. All dollar amounts are expressed in U.S. currency and results are reported in accordance with United States generally accepted accounting principles except where noted otherwise.

2019 First Quarter Financial Summary:

• Revenue increased to $416,000, compared to $239,000 in the first quarter of 2018


• Adjusted EBITDA was ($2.1 million), compared to ($1.8 million) in Q1-2018


• Cash and short-term investments totaled $8.6 million as at March 31, 2019

Recent Developments:

• Appointed André Godin to the position of President and Chief Financial Officer


• Entered into a definitive worldwide agreement with Aquestive Therapeutics, Inc. for the co-development and commercialization of Tadalafil oral films for the treatment of erectile dysfunction


• Received from the United States Patent and Trademark Office a patent covering design and manufacturing of topical oral films for the topical treatment of diseases of the oral mucosa using mucocoadhesive particles


• Presented an overview of the Company’s business at the 2019 Bloom Burton & Co. Healthcare Investor Conference 


• Promoted the Company’s VersaFilm^® and VetaFilm™ oral film contract development and manufacturing organization, or CDMO, services capabilities at CPhI North America


• Filed a non-provisional U.S. patent application for oil-based active ingredients


• Promoted VetaFilm™ oral film technology at the Human Biotech & Animal Health Business Partnering Summit


• Presented two Montelukast poster presentations at the 14th International Conference on Alzheimer's & Parkinson's Diseases


• Received a Complete Response Letter requesting additional information, but no new bioequivalence study, from the U.S. Food and Drug Administration related to its resubmitted RIZAPORT^® new drug application (“NDA”); Company’s objective is to resubmit the RIZAPORT^® NDA before the end of Q3-2019


• Received a Japanese patent for RIZAPORT^® VersaFilm^®


• Announced Montreal's Douglas Mental Health University Institute as an additional Montelukast VersaFilm^® Phase 2a clinical trial site in Canada


• Appointed Dr. Rodolphe Obeid to the position of Vice President, Operations

"The agreement we secured with Aquestive represents a continuation of IntelGenx’s commitment to commercialize our pipeline of innovative oral film products with strong partners,” commented Dr. Horst G. Zerbe, CEO of IntelGenx. "We look forward to updating our stakeholders as we execute on a number of major objectives over the next several quarters.”

Financial Results:

Total revenues for the three-month period ended March 31, 2019 amounted to $416,000, an increase of $177,000 compared to $239,000 for the three-month period ended March 31, 2018. The increase is mainly attributable to an increase in R&D milestone revenues offset by a decrease in R&D revenues.

Operating costs and expenses were $2.7 million for the first quarter 2019, versus $2.3 million for the corresponding three-month period of 2018. The increase for the three-month period ended March 31, 2019 is mainly attributable to a $424,000 increase in Selling, General and Administrative expenses.

For Q1-2019, the Company had an operating loss of $2.3 million, compared to operating loss of $2.0 million for the comparable period of 2018.

Net comprehensive loss was $2.3 million, or $0.03 on a basic and diluted per share basis, for both the three-month period ended March 31, 2019 and the comparable period of 2018.

As of March 31, 2019, the Company’s cash and short-term investments totalled $8.6 million.

Conference Call Details:

IntelGenx will host a conference call to discuss these 2019 first quarter financial results today on May 9, 2019, at 4:30 p.m. ET. The dial-in number for the conference call is  (833) 231-8269 (Canada and United States) or (647) 689-4114 (International), conference ID 4695936. A live and archived webcast of the call will be available on IntelGenx’s website at www.intelgenx.com under “Presentations” in the Investors section.

About IntelGenx:

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm^® and VetaFilm™ technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements:

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities and www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source: IntelGenx Technologies Corp.

For more information, please contact:


Stephen Kilmer

Investor Relations 

(514) 331-7440 ext 232

stephen@intelgenx.com

Or

Andre Godin, CPA, CA

President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, May 08, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that it has entered into a definitive worldwide agreement with Aquestive Therapeutics, Inc. (NASDAQ:AQST) (“Aquestive”), a specialty pharmaceutical company focused on developing and commercializing differentiated products to solve therapeutic problems, for the co-development and commercialization of Tadalafil oral films (the “Agreement”) for the treatment of erectile dysfunction (“ED”).

Under the terms of the Agreement, IntelGenx and Aquestive will each grant to the other exclusive worldwide licenses to their respective intellectual property relating to tadalafil oral film formulation and manufacturing. The companies will jointly undertake further co-development and commercialization of Tadalafil oral film products, and will equally share (50/50) net profits from worldwide product sales. In connection with the Agreement, Aquestive has also granted a non-exclusive, royalty bearing U.S. license to any of its intellectual property that may relate to the formulation and manufacturing of IntelGenx’s rizatriptan oral film product, RIZAPORT^®. IntelGenx will pay Aquestive a royalty equal to 10% of all payments received by IntelGenx from third parties for U.S. product related milestones and sales

“We are pleased to collaborate with Aquestive given the synergy of our oral film technologies, particularly pertaining to the development and commercialization of tadalafil oral films,” said Dr. Horst G. Zerbe, President and CEO of IntelGenx. “The launch of a partnered tadalafil oral film in the U.S. has the potential to bring a product to market sooner and maximize the commercial opportunity for IntelGenx, Aquestive, and our respective shareholders.”

“IntelGenx is a natural partner for our tadalafil oral film program,” said Dan Barber, Chief Operating Officer of Aquestive. “This partnership will allow us to continue to stay focused on advancing our commercial portfolio and late stage CNS programs, while working with IntelGenx to realize the full potential for tadalafil oral film on a global basis. We are also pleased to provide access to our extensive intellectual property portfolio for IntelGenx’s RIZAPORT^® product.”

Aquestive previously submitted new drug application (“NDA”) for its tadalafil oral film for the treatment of ED to the U.S. Food and Drug Administration (“FDA”). In November 2018, Aquestive received a complete response letter (“CRL”) from the FDA requesting limited additional data from healthy volunteers. Under the terms of the Agreement, both companies will cooperate in responding to the FDA’s CRL.

About Aquestive Therapeutics

Aquestive Therapeutics is a specialty pharmaceutical company that applies innovative technology to solve therapeutic problems and improve medicines for patients. Aquestive is advancing a late-stage proprietary product pipeline to treat CNS conditions and provide alternatives to invasively-administered standard of care therapies. The company also collaborates with pharmaceutical partners to bring new molecules to market using proprietary, best-in-class technologies, like PharmFilm^®, and has proven capabilities for drug development and commercialization. For more information about the company, please visit www.aquestive.com.

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ and VetaFilm™ technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For IntelGenx


Stephen Kilmer

Investor Relations 

(514) 331-7440 ext 232

stephen@intelgenx.com

Or

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

For Aquestive

Media inquiries:

Christopher Hippolyte

212-364-0458

christopher.hippolyte@syneoshealth.com 

Investor inquiries:

Stephanie Carrington

646-277-1282

stephanie.carrington@icrinc.com

SAINT LAURENT, Quebec, May 01, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that the United States Patent and Trademark Office has issued U.S. Patent 10,272,038 entitled “Film Dosage Form with Extended Release Mucoadhesive Particles.” The patent covers the design and manufacturing of topical oral films (“TOF”) for the local (topical) treatment of diseases of the oral mucosa using mucoadhesive particles.

This patent is in the same family as U.S. Patent 9,668,970 – issued to IntelGenx in June 2017 – and provides broader coverage for IntelGenx’s proprietary technology, which is intended to provide sustained release of an active agent to a target area of the oral cavity. The technology is useful for the topical treatment of oral diseases and conditions such as gingivitis, buccal ulcers, canker sores, Sjögren’s syndrome, oral mucositis and Behcet’s disease.

“This is the second orange book eligible U.S patent IntelGenx has been granted for our topical oral film technology, and it reflects our strategy to broaden and diversify our intellectual property portfolio to obtain protection for the many applications of our VersaFilm^® technology,” said Horst G. Zerbe, CEO of IntelGenx. “In this case, we believe our technology offers a novel and potentially superior treatment option for oral diseases such as Sjögren’s syndrome and oral mucositis, both of which represent significant unmet medical need and a large market opportunity.”

The market opportunity for treatments of oral disease and conditions is large and growing. For example, available data indicate that the global market for oral mucositis treatments is approximately USD$2 billion, and is expected to grow at a compound annual rate of approximately 7% through to 2024, while the global Sjögren’s syndrome market is expected to reach USD$2 billion by 2024.

About IntelGenx Topical Oral Film

IntelGenx’s TOF has a unique mode of action. It facilitates the controlled release of an active agent to the buccal cavity and its transport through the oral mucosa, while avoiding the discomfort often associated with conventional long lasting mucoadhesive films or tablets. The controlled release of an active agent for local action in the buccal cavity is achieved by providing an oral film in which small sized mucoadhesive particles containing the active agent are dispersed in a disintegrating film matrix. Upon administration in the oral cavity, the film quickly disintegrates and releases the mucoadhesive particles which will bind to the oral mucosa. The active agent can be released from the mucoadhesive particles over a prolonged period of time as the mucoadhesive material slowly dissolves or erodes.

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm^® and VetaFilm™ technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp. 

For IntelGenx


Stephen Kilmer

Investor Relations 

(514) 331-7440 ext 232

stephen@intelgenx.com 

Or

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, April 25, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that its Executive Vice-President and Chief Financial Officer, Andre Godin, is scheduled to present at the 2019 Bloom Burton & Co. Healthcare Investor Conference on April 30, 2019 at 2:30 p.m. ET at the Metro Toronto Convention Centre.

Mr. Godin will provide an overview of IntelGenx’s business during the presentation and will be available to participate in one-on-one meetings with investors who are registered to attend the conference. 

The presentation will be webcast live and archived for 90 days on the Company's website, at www.intelgenx.com, under "Presentations".

About IntelGenx
Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm^® and VetaFilm™ technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements 
This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For IntelGenx:

 

Stephen Kilmer

Investor Relations

(514) 331-7440 ext 232

stephen@intelgenx.com

 

Or

 

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, April 23, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that it will promote its contract development and manufacturing organization (“CDMO”) services capabilities using its existing proprietary VersaFilm^TM and VetaFilm™ oral film technologies at CPhI North America taking place on April 30-May 2, 2019 in Chicago, IL.

VersaFilm™ and VetaFilm™ are IntelGenx’s proprietary oral drug delivery technology platforms for human and veterinary applications, respectively. They enable the development of oral films with potential to improve absorption, accelerate onset of action, reduce side effects, ease administration and improve patient compliance. 

“We are excited to be a part of the CPhI North America,” said Horst G. Zerbe, President and CEO of IntelGenx. “The conference is an excellent forum to demonstrate to the pharma world our CDMO capabilities and how our oral film technologies can help addressing unmet medical needs.”

About IntelGenx
Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ and VetaFilm^TM technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements 
This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx' plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For IntelGenx:
 
Stephen Kilmer
Investor Relations
(514) 331-7440 ext 232
stephen@intelgenx.com
 
Or
 
Andre Godin, CPA, CA
Executive Vice-President and CFO
IntelGenx Corp.
(514) 331-7440 ext 203
andre@intelgenx.com 

SAINT LAURENT, Quebec, April 16, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that it has filed a new non-provisional patent application at the Unites States Patent and Trademark Office entitled “Lipophilic Active Oral Film Formulation And Method Of Making The Same.”

The patent application covers a newly-developed platform that enables the incorporation of oil-based (lipophilic) active ingredients into oral film formulations. This new platform, suitable for both VersaFilm^TM and VetaFilm^TM, is compatible with several of IntelGenx’ current projects including Montelukast, Loxapine and cannabis-infused films. The technology may also be used when more than one active ingredients, such as THC and CBD, are applied in a single film product.

“This new filing adds to the global intellectual property estate that we are building for VersaFilm^TM and VetaFilm^TM,” said Dr. Horst G. Zerbe, President and CEO of IntelGenx. “We anticipate that this application will also be filed in several other international jurisdictions as the application progresses in the United States.”  

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm^TM and VetaFilm^TM technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For more information please contact:

Stephen Kilmer
Investor Relations
(514) 331-7440 ext 232
stephen@intelgenx.com

Or

Andre Godin, CPA, CA
Executive Vice-President and CFO
IntelGenx Corp.
(514) 331-7440 ext 203
andre@intelgenx.com

SAINT LAURENT, Quebec, April 08, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that it will promote its proprietary VetaFilm™ oral film technology for companion animal drug delivery at the Human Biotech & Animal Health Business Partnering Summit taking place on April 9, 2019 in Boston, MA.

VetaFilm™ is a rapidly disintegrating oral film designed to improve drug performance, promote compliance and increase the ease of drug administration in companion animals. As small as a postage stamp, the film can be flavoured to appeal to companion animals for spontaneous intake and will adhere on contact in the mouth.  Moreover, VetaFilm™ buccal absorption has the potential for improved drug efficacy, faster onset of action and reduced side effects by avoiding first-pass metabolism.

VetaFilm™ technology is compatible with a wide variety of actives such as cannabinoids. According to primary research conducted by IntelGenx’s team, cannabinoid-containing VetaFilm™ animal health products are in high demand by pet owners. Recent studies have shown that cannabidiol significantly reduces pain and improves mobility in dogs with osteoarthritis¹.

“We are excited to be a part of the Human Biotech & Animal Health Business Partnering Summit,” said Horst G. Zerbe, President and CEO of IntelGenx. “The Summit is an excellent forum to demonstrate the innovative possibilities with VetaFilm™ and how this oral film technology can serve unmet medical needs in veterinary health.”

Reference
1 Gamble L et al., “Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs”, Front. Vet. Sci., 23 July 2018.

About IntelGenx
Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ and VetaFilm^TM technology platforms.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for oral film technology platforms, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements 
This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx' plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

For IntelGenx:

 

Stephen Kilmer

Investor Relations

(514) 331-7440 ext 232

stephen@intelgenx.com

 

Or

 

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, April 04, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced its two Montelukast poster presentations received positive and constructive feedback from the Alzheimer’s Disease (AD) scientific community at the 14^th International Conference on Alzheimer’s & Parkinson’s Diseases in Lisbon, Portugal. The poster presentations were presented in collaboration with Prof. Dr. Ludwig Aigner’s group at the Paracelsus Medical University in Salzburg.

The first poster entitled “The Leukotriene Receptor Antagonist Montelukast Improves Cognitive Function in the 5xFAD Model of Alzheimer’s Disease” presented a preclinical study of Montelukast in an AD mouse model, whereby 45 five-month old mice were treated with either Montelukast or placebo via an adhesive buccal film for 13 weeks. The effects of cognition were assessed in the mice through several behavioural tests and overall results demonstrated that Montelukast improved learning behaviour, and that treatment with higher doses of Montelukast displayed a trend toward better long-term memory. The poster summarized that long-term treatment with Montelukast in the mouse model improved cognitive function and increased the number of microglia without influencing the pathology of the amyloid plaques. In addition, the microglia were observed to be distant from the amyloid plaques, rather than concentrated around these plaques as is typically seen in AD. This increase of microglia distant from amyloid plaques might be novel mode of action of Montelukast, since there is growing evidence that microglia exist in many different stages; Montelukast might increase the population of beneficial microglia.

The second poster presentation entitled “The BUENA Study: A Phase 2A Clinical Trial to Test Safety and Efficacy of Montelukast VersaFilm™ in Alzheimer’s Patients” provided a background summary to the randomized, double-blind placebo controlled study that is currently ongoing across nine Canadian research sites.

“We have increasing and supportive evidence for the potential of Montelukast VersaFilm™ as a viable treatment for AD,” said Dr. Horst G. Zerbe, President and CEO of IntelGenx. “We have had glowing feedback from respected leaders in the AD community, as well as interest from the U.S. National Institutes of Health, which we believe would be supportive of future clinical trials in the United States.”

About Montelukast VersaFilm™:

Montelukast is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast is a CysLT1 antagonist; it blocks the action of leukotriene D4, a natural substance produced in the body involved in inflammation, (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the narrowing of bronchioles otherwise caused by the leukotriene and results in less inflammation. IntelGenx’s Montelukast buccal film offers a distinct dosage form that improves bioavailability and removes the need for water intake. The latest formulation successfully demonstrated enhanced bioavailability as compared with the brand tablet in a pilot study.

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ technology platform.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for the VersaFilm™ technology platform, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source: IntelGenx Technologies Corp.

For more information please contact: Stephen Kilmer Investor Relations (514) 331-7440 ext 232 stephen@intelgenx.com  Or Andre Godin, CPA, CA Executive Vice-President and CFO IntelGenx Corp. (514) 331-7440 ext 203 andre@intelgenx.com 

SAINT LAURENT, Quebec, March 27, 2019 (GLOBE NEWSWIRE) -- IntelGenx Technologies Corp. ("IntelGenx", or the “Company”) (TSX-V: IGX) (OTC.QX:IGXT) announced today that the Company’s board of directors granted 100,000 options to acquire 100,000 common shares under the 2016 Stock Option Plan to Rodolphe Obeid, VP Operations of IntelGenx Corp.

The options have an exercise price of US$0.69 (CAD$0.92), vest over a period of two years at the rate of 25% every six months and expire on March 26, 2029.

About IntelGenx:

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ technology platform.

IntelGenx' highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services.  IntelGenx' state-of-the-art manufacturing facility, established for the VersaFilm™ technology platform, supports lab-scale to pilot and commercial-scale production, offering full service capabilities to its clients. More information about the Company can be found at www.intelgenx.com.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange), nor the OTCQX accepts responsibility for the adequacy or accuracy of this release.

Contact:
IntelGenx Technologies Corp.
Ingrid Zerbe
Corporate Secretary
514-331-7440
ingrid@intelgenx.com 
www.intelgenx.com 

Renowned Neurologist Dr. Serge Gauthier to Serve as Site’s Lead Investigator

For more information please contact:


Stephen Kilmer

Investor Relations 

(514) 331-7440 ext 232

stephen@intelgenx.com

Or

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, Feb. 11, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that it has received a Decision to Grant notice from the Japanese Patent Office (JPO) to issue a patent entitled “Instantly wettable oral film dosage form without surfactant or polyalcohol.”

Once the JPO’s administrative process is complete, the patent that issues from this application will provide intellectual property protection in Japan for the formulation of IntelGenx’ VersaFilm™ technology used in its RIZAPORT^® product, through 2034. RIZAPORT^® is an oral thin film formulation of rizatriptan benzoate for the treatment of acute migraines. The Decision to Grant notice is the final approval stage and precedes actual granting, which is expected shortly. The identification number is Japanese Patent Application 2016-530631. IntelGenx received a similar formulation patent covering its RIZAPORT^® VersaFilm™ technology from the European Patent Office in 2018 and from the United States Patent and Trademark Office in 2016, and has additional applications pending in other countries.

“This allowance adds to the formidable intellectual property estate that we are building for RIZAPORT^® around the globe,” said Dr. Horst G. Zerbe, President and CEO of IntelGenx. “Japan is the world’s third-largest pharmaceuticals market and, as such, represents a significant commercial opportunity for RIZAPORT^®.  Moving forward, we will be actively seeking a marketing partner for the product in this jurisdiction.”

About RIZAPORT^®:

RIZAPORT^® is a patent protected proprietary oral thin film formulation of rizatriptan benzoate, a 5-HT1 receptor agonist and the active drug in Merck & Co.'s Maxalt^®.

Rizatriptan is considered to be one of the most effective oral triptans, a class of molecules that constricts blood vessels in the brain to relieve swelling and other migraine symptoms. RIZAPORT^® is based on IntelGenx’ proprietary VersaFilm™ technology.  It dissolves rapidly and releases its active ingredient in the mouth.  The administration method of the RIZAPORT^® oral soluble film, which does not require the patient to swallow a pill or consume water, along with its neutral flavor, presents a potentially attractive therapeutic alternative for migraine patients, specifically for patients who suffer from migraine-related nausea, estimated to be approximately 80% of the total migraine patient population and patients suffering from dysphagia (difficulty swallowing)¹.

Reference:

¹ Lipton RB, Buse DC, Saiers J, Fanning KM, Serrano D, Reed ML. (2013) Frequency and burden of headache-related nausea: results from the American Migraine Prevalence and Prevention (AMPP) study, Headache. 2013 Jan;53(1):93-103.

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ technology platform.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for the VersaFilm™ technology platform, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx' operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx' plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For more information, please contact:


Stephen Kilmer

Investor Relations 

(514) 331-7440 ext 232

stephen@intelgenx.com

Or

Andre Godin, CPA, CA

Executive Vice-President and CFO

IntelGenx Corp.

(514) 331-7440 ext 203

andre@intelgenx.com

SAINT LAURENT, Quebec, Jan. 30, 2019 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCQX:IGXT) (“IntelGenx”), a leading oral drug delivery company, today announced that the U.S. Food and Drug Administration (“FDA”) has performed a Pre-Approval Inspection (“PAI”) of the company’s Health Canada-certified cGMP manufacturing facility in Montreal. The PAI is related to the IntelGenx New Drug Application (“NDA”) for RIZAPORT^®, a VersaFilm™ oral soluble film for the treatment of acute migraines. At the conclusion of the PAI on January 25, the FDA issued a Form 483 with five inspectional observations.

“We appreciate the thoroughness of the FDA’s review of our facility, and we are confident that we will be able to address the FDA’s observations within the 15-day response timeframe,” said Dr. Horst G. Zerbe, President and CEO of IntelGenx. “As we continue to advance through the NDA process, IntelGenx is excited to have completed another important milestone toward U.S. approval.”

The FDA has assigned a Prescription Drug User Fee Act goal date of April 1, 2019, for completion of the review of the resubmitted NDA for RIZAPORT^®. IntelGenx does not expect the inspectional observations to impact the timeline for the FDA’s decision on the approval of RIZAPORT^®.

In December 2018, IntelGenx entered into a definitive licensing, development and supply agreement granting Gensco^® Pharma the exclusive right to commercialize the IntelGenx RIZAPORT^® product in the United States.

About RIZAPORT^®:

RIZAPORT^® is a patent protected proprietary oral thin film formulation of rizatriptan benzoate, a 5-HT1 receptor agonist and the active drug in Merck & Co.'s Maxalt^®.

Rizatriptan is considered to be one of the most effective oral triptans, a class of molecules that constricts blood vessels in the brain to relieve swelling and other migraine symptoms. RIZAPORT^® is based on IntelGenx’s proprietary VersaFilm™ technology. It dissolves rapidly and releases its active ingredient in the mouth. The administration method of the RIZAPORT^® oral soluble film, which does not require the patient to swallow a pill or consume water, along with its neutral flavor, presents a potentially attractive therapeutic alternative for migraine patients, specifically for patients who suffer from migraine-related nausea, estimated to be approximately 80% of the total migraine patient population and patients suffering from dysphagia (difficulty swallowing)¹.

References:

¹ Lipton RB, Buse DC, Saiers J, Fanning KM, Serrano D, Reed ML. (2013) Frequency and burden of headache-related nausea: results from the American Migraine Prevalence and Prevention (AMPP) study, Headache. 2013 Jan;53(1):93-103.

About IntelGenx

Established in 2003, IntelGenx is a leading oral drug delivery company primarily focused on the development and manufacturing of innovative pharmaceutical oral films based on its proprietary VersaFilm™ technology platform.

IntelGenx's highly skilled team provides comprehensive pharmaceuticals services to pharmaceutical partners, including R&D, analytical method development, clinical monitoring, IP and regulatory services. IntelGenx's state-of-the-art manufacturing facility, which was established for the VersaFilm™ technology platform, offers by supporting lab-scale to pilot- and commercial-scale production. More information about the company can be found at www.intelgenx.com.

Forward Looking Statements

This document may contain forward-looking information about IntelGenx's operating results and business prospects that involve substantial risks and uncertainties. Statements that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended. These statements include, but are not limited to, statements about IntelGenx's plans, objectives, expectations, strategies, intentions or other characterizations of future events or circumstances and are generally identified by the words "may," "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "could," "would," and similar expressions. All forward looking statements are expressly qualified in their entirety by this cautionary statement. Because these forward-looking statements are subject to a number of risks and uncertainties, IntelGenx's actual results could differ materially from those expressed or implied by these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed under the heading "Risk Factors" in IntelGenx's annual report on Form 10-K, filed with the United States Securities and Exchange Commission and available at www.sec.gov, and also filed with Canadian securities regulatory authorities at www.sedar.com. IntelGenx assumes no obligation to update any such forward-looking statements.

Each of the TSX Venture Exchange and OTCQX has neither approved nor disapproved the contents of this press release.  Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Source:  IntelGenx Technologies Corp.

For more information please contact: Stephen Kilmer Investor Relations (514) 331-7440 ext 232 stephen@intelgenx.com   Or Andre Godin, CPA, CA Executive Vice-President and CFO IntelGenx Corp. (514) 331-7440 ext 203 andre@intelgenx.com